Open Access Original article

Efficient surface functionalization of wound dressings by a phytoactive nanocoating refractory to Candida albicans biofilm development

Ion Anghel12, Alina Maria Holban3, Ecaterina Andronescu4, Alexandru Mihai Grumezescu4* and Mariana Carmen Chifiriuc3

Author Affiliations

1 ENT, “Carol Davila” University of Medicine and Pharmacy, TraianVuia no.6, Bucharest, 020956, Romania

2 Doctor Anghel Medical Center, Theodor Sperantia Street, Bucharest, 30932, Romania

3 Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Bucharest, Romania

4 Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Bucharest, 011061, Romania

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Biointerphases 2013, 8:12  doi:10.1186/1559-4106-8-12

Published: 25 April 2013

Abstract

The present study reports the fabrication and characterization of a novel nanostructured phyto-bioactive coated rayon/polyester wound dressing (WD) surface refractory to Candida albicans adhesion, colonization and biofilm formation, based on functionalized magnetite nanoparticles and Anethum graveolens (AG) and Salvia officinalis (SO) essential oils (EOs). TEM, XRD, TGA, FT-IR were used for the characterization of the fabricated nanobiocoated WDs. Using magnetic nanoparticles for the stabilization and controlled release of EOs, the activity of natural volatile compounds is significantly enhanced and their effect is stable during time. For this reason the nanobiocoated surfaces exhibited a longer term anti-biofilm effect, maintained for at least 72 h. Besides their excellent anti- adherence properties, the proposed solutions exhibit the advantage of using vegetal natural compounds, which are less toxic and easily biodegradable in comparison with synthetic antifungal drugs, representing thus promising approaches for the development of successful ways to control and prevent fungal biofilms associated infections.

Keywords:
Biocompatible surfaces; Phytoactive nanosystems; Anti-biofilm strategy